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Cell fate determination in the Drosophila central nervous system
Reference
G07937
Principal Investigator / Supervisor
Professor Guy Justin Clive Tear
Co-Investigators /
Co-Supervisors
Institution
King's College London
Department
GKT School of Medicine
Funding type
Research
Value (£)
165,441
Status
Completed
Type
Research Grant
Start date
10/11/1997
End date
31/03/2001
Duration
41 months
Abstract
The aim of this proposed study is to characterise novel genes required for the determination of cells within the central nervous system (CNS) of Drosophila We have isolated a number that affect cell fate choice in the CNS. The phenotypes of these mutants will be studied in detail and those that affect cell fate choice late in the neuroblast lineage will be characterised molecularly. Once the novel gene products have been identified, misexpression experiments will be used to assay their ability to switch the fate of individual cells within the nervous system. We also hope to isolate vertebrate homologues of any novel genes in order to identify functional domains and to assess the conservation of developmental mechanism.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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