BBSRC Portfolio Analyser
Award details
Regulation of the eukaryotic cap-binding complex eIF4F
Reference
G07919
Principal Investigator / Supervisor
Professor John McCarthy
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
170,459
Status
Completed
Type
Research Grant
Start date
20/06/1997
End date
20/06/2000
Duration
36 months
Abstract
The eukaryotic cap-binding complex eukaryotic initiation factor eIF4F mediates the interaction of ribosomes with mRNA, thus playing a key role in translational initiation. It is also a focal point of regulation of gene expression. We will use a combination of genetic and biochemical methods to study the function and regulation of this complex in both budding and fission yeast. The experiments will include: (i) mutational and competition analysis of eIF4F component interactions in Saccharomyces cerevisiae; (ii) in vitro analysis of mammalian-type regulatory circuits in S. pombe; (iii) in vitro biochemical studies of eIF4F interactions using cell-free translation systems and recombinant eIFs and eIF domains.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search