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Genetic dissection of signalling mechanisms underlying developmental fate assignment in insect epithelia

Reference	G07826
Principal Investigator / Supervisor	Dr J Whittle
Co-Investigators / Co-Supervisors	Dr Roger Phillips
Institution	University of Sussex
Department	Biology and Environmental Science
Funding type	Research
Value (£)	267,258
Status	Completed
Type	Research Grant
Start date	04/08/1997
End date	04/08/2000
Duration	36 months

Abstract

We will exploit efficient genetic procedures which we have evolved, based upon induced mosaics, allowing us to select new mutations affecting insect epithelial patterning. Mutations in several important transduction pathways cause characteristic abnormalities in patterning. Our goal is a complete inventory and functional 'network' account of this developmental system. The position of each gene in this network relative to known genes in these pathways will be assayed by specific genetic and molecular biological criteria. We have set up explicit collaborative arrangements to utilise these products efficiently.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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