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Molecular analysis of circadian temperature compensation in Drosophila
Reference
G06874
Principal Investigator / Supervisor
Professor Charalambos Kyriacou
Co-Investigators /
Co-Supervisors
Institution
University of Leicester
Department
Genetics
Funding type
Research
Value (£)
161,910
Status
Completed
Type
Research Grant
Start date
01/11/1996
End date
31/01/2000
Duration
39 months
Abstract
Comparative and mutational analysis of the Thr-Gly repeat of the PERIOD (PER) protein in Drosophila melanogaster has revealed that it plays a major role in the temperature compensation of the circadian clock, and that this may be mediated by interactions with other regions of PER. Molecular and immunological methods will be used to examine the circadian dynamics of PER and TIMELESS (TIM-the PER partner), and their association in these mutants, both in vivo, and in vitro. In addition we will examine these putative interactions using both the yeast two-hybrid system and in vitro associations of the relevant PER peptides. The results will illuminate the molecular basis of circadian temperature compensation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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