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Genetic analysis of the determinants of selective incomplete protein degradation using yeast Hsp82 protein as a model
Reference
G06776
Principal Investigator / Supervisor
Professor Peter William Piper
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Structural Molecular Biology
Funding type
Research
Value (£)
142,377
Status
Completed
Type
Research Grant
Start date
01/02/1997
End date
30/04/2000
Duration
39 months
Abstract
Only a few signals for differential, selective protein turnover in eukaryotic cells have been identified. In all instances the target protein is completely degraded. However there is mounting evidence that, for some proteins, the ubiquitination system catalyses an incomplete degradation. This project aims to identify genetically: (i) the activities responsible for partial degradation of Saccharomyces cerevisiae Hsp82 and Candida albicans Hsp90 to their stable C-terminal domain subfragments; and (ii) the elements of Hsp82 structure that cause recognition of this protein but not the 98% homologous Hsc82 as a substrate for this incomplete degradation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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