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Translational regulation during early embryogenesis in Xenopus laevis

Reference	G06562
Principal Investigator / Supervisor	Dr Virginia Pain
Co-Investigators / Co-Supervisors	Professor Simon Morley
Institution	University of Sussex
Department	Sch of Life Sciences
Funding type	Research
Value (£)	140,559
Status	Completed
Type	Research Grant
Start date	01/10/1996
End date	01/10/1999
Duration	36 months

Abstract

The regulation of translation of maternally-expressed mRNAs is a key mechanism determining patterns of gene expression during early development. The first step in the recruitment of an mRNA molecule for translation is interaction with an initiation factor complex that recognizes the 5' terminal cap structure. We have demonstrated a link between stimulation of protein synthesis during meiotic maturation of Xenopus oocytes and enhanced phosphorylation and association of the initiation factors in this complex. Here we propose to analyse changes in this step in translation during embryogenesis, in particular focusing on the early cell cycles following fertilisation. Complementary studies will examine cell-cycle related oscillations in the function of these factors in cycling extracts prepared from activated Xenopus eggs.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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