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Identification of novel mutations affecting the development of the zebrafish central nervous system
Reference
G06123
Principal Investigator / Supervisor
Professor Stephen Wilson
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Cell and Developmental Biology
Funding type
Research
Value (£)
245,906
Status
Completed
Type
Research Grant
Start date
16/09/1996
End date
16/09/2000
Duration
48 months
Abstract
Our research is concerned with the mechanisms that underly regional patterning and neuronal differentiation in the vertebrate nervous system. Using the zebrafish embryo as our experimental model system, we have identified, some of the genes that may be involved in these patterning processes. In this programme grant we aim to generate and characterise novel genetic mutations that affect the patterning of the CNS. Chemical mutagens will be used to induce mutations in the sperm of male fish which will subsequently be crossed to wild type females to generate heterozygous F1 fish. Mutations will be screened in homozygous F3 embryos. Novel mutations will be characterised using a variety of probes and techniques.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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