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Control of yeast mRNA degradation in response to glucose
Reference
G06078
Principal Investigator / Supervisor
Professor Al Brown
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
183,906
Status
Completed
Type
Research Grant
Start date
01/09/1996
End date
01/01/2001
Duration
52 months
Abstract
Glucose exerts numerous and profound effects upon the yeast cell, and many genes are regulated in response to glucose. mRNA degradation plays an important role in eukaryotic gene regulation. Indeed, changes in the stability of an mRNA are known to have significant effects upon the expression of its cognate gene. We have shown that glucose accelerates the degradation of the yeast PCK1 mRNA (encoding phosphoenolpyruvate carboxykinase). In this study we will investigate, for the first time, how yeast mRNA degradation pathways are modulated by an external stimulus. More specifically, we will (1) establish whether glucose stimulates PCK1 mRNA degradation by activating alternative mRNA degradation pathways, (2) determine whether glucose influences the relationship between PCK1 mRNA degradation and translation, and (3) identify regulatory factors which interact specifically with the PCK1mRNA to control its degradation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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