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Repressor-operator interactions in the Streptomyces temperate phage thetaC31
Reference
G05986
Principal Investigator / Supervisor
Professor Margaret Smith
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
School of Molecular Medical Sciences
Funding type
Research
Value (£)
156,107
Status
Completed
Type
Research Grant
Start date
01/05/1996
End date
30/04/1999
Duration
36 months
Abstract
Two features of the unusual and complex regulatory system which controls lytic growth in the Streptomyces temperature phage thetaC31 will be studied. Firstly, the protein-DNA interactions between inframe, N-terminally different repressor isoforms and the 18 operators located throughout the phage genome will be characterised in vitro and the functional differences between the isoforms determined. Secondly, an in vivo, genetic approach will be used to ascertain the roles of the multiple operators in thetaC31.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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