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DNA binding and transcriptional activity of a family of yeast proteins
Reference
G04910
Principal Investigator / Supervisor
Professor Richard Reece
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
93,225
Status
Completed
Type
Research Grant
Start date
01/03/1996
End date
01/03/1998
Duration
24 months
Abstract
A family of fungal transcriptional activators, related to GAL4 in their DNA binding domain, will be analysed to address the following issues; a) how do a family of related DNA binding proteins distinguish their own particular DNA site, b) what are the targets of this family of proteins allowing them to act as activators, and c) do negative regulators control the activity of various family members. Understanding how a family of proteins adapt to use a common DNA-binding motif to recognise different DNA sites will give insight into the process of molecular evolution, while the identification of proteins that interact with transcriptional activators will lead to a better understanding of the mechanisms of activation and repression.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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