BBSRC Portfolio Analyser
Award details
Molecular genetic analysis of the Drosophila Trk-related receptor Dror and its signalling cascade
Reference
G04907
Principal Investigator / Supervisor
Professor Clive Wilson
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
University of Kent Department
Funding type
Research
Value (£)
157,145
Status
Completed
Type
Research Grant
Start date
06/02/1996
End date
06/05/1999
Duration
39 months
Abstract
The neural-specific Drosophila gene Dror encodes a member of the Ror receptor tyrosine kinase family, which is closely related to the vertebrate neurotrophin receptors or Trks. Dror is required for normal neural development, and like the Trks, it may promote neuronal survival. In this proposal, we plan to generate new mutant Dror alleles and to identify genes that genetically interact with Dror, which may encode components of the Dror signalling cascade. Preliminary experiments indicate that the Dror receptor signals via a novel intracellular pathway. Our ultimate objectives are to characterise this pathway and the Dror ligand. These studies should provide general insights into the signalling mechanisms of Trk-related receptors.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search