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Transcription activated by the Escherichia coli Melr protein

Reference	G04260
Principal Investigator / Supervisor	Professor Steve Busby
Co-Investigators / Co-Supervisors
Institution	University of Birmingham
Department	Sch of Geography, Earth & Env Sciences
Funding type	Research
Value (£)	154,212
Status	Completed
Type	Research Grant
Start date	14/11/1994
End date	30/04/1998
Duration	41 months

Abstract

Me1R is an E coli transcription activator. Our objectives are: (1) to find the mechanisms by which active Me1R stimulates transcription initiation. To do this we will isolate mutations resulting in constitutively-active Me1R, purify the mutant protein and study DNA binding and transcription activation in vitro. (2) to obtain structural data on Me1R by overexpressing and purifying the C-terminal DNA-binding domain and initiating an NMR study of the structure. (3) to locate segments of Me1R involved in the triggering of activity by melibiose.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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