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Analysis of gene expression and subcellular protein localisation in individual Bacillus subtilis cells
Reference
G04143
Principal Investigator / Supervisor
Professor Jeffery Errington
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Sir William Dunn Sch of Pathology
Funding type
Research
Value (£)
195,536
Status
Completed
Type
Research Grant
Start date
01/04/1995
End date
01/04/1998
Duration
36 months
Abstract
Sporulation in B. subtilis is a simple developmental system involving the differentiation of 2 cells and the synthesis and assembly of subcellular morphological structures. We have recently developed methods to visualise gene expression in individual sporulating cells. We wish to develop improved methods and apply these to a range of problems including the important hypotheses that the mechanisms regulating gene expression during development serve to coordinate the developmental pathways of the two cells and to keep the programmes of gene expression in register with morphological events. We will also develop and apply new light microscopical methods for determining the subcellular localisation of specific proteins.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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