BBSRC Portfolio Analyser
Award details
Mammary-specific targeting of JAK2 protein tyrosine kinase
Reference
G04085
Principal Investigator / Supervisor
Professor Alan Clarke
Co-Investigators /
Co-Supervisors
Professor Christine Watson
Institution
University of Edinburgh
Department
Pathology
Funding type
Research
Value (£)
185,369
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
06/01/1999
Duration
40 months
Abstract
The gene encoding JAK2, a non-receptor tyrosine kinase, will be deleted using orthodox gene targeting techniques to study the role, if any, of JAK2 in embryonic development. The likely outcome is a severe mutation, therefore a tissue-specific gene targeting methodology based on the cre/lox recombinase system will be used to investigate the role of JAK2 in signal transduction in the mammary gland during growth and differentiation. This approach will be applicable to the abrogation of function of any gene product specifically in the mammary gland whilst not affecting expression in extra-mammary tissues and will serve as a model system for the tissue-specific functional analysis of other genes expressed in the mammary gland.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search