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Fibroblast growth factors and control of bud initiation and outgrowth in developing limbs of birds, mammals and reptiles
Reference
G04033
Principal Investigator / Supervisor
Professor Emeritus Cheryll Tickle
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Cell and Developmental Biology
Funding type
Research
Value (£)
90,322
Status
Completed
Type
Research Grant
Start date
01/07/1995
End date
01/07/1997
Duration
24 months
Abstract
We wish to understand the cellular and molecular mechanisms involved in initiation of limb bud development and how locations and numbers of limbs are controlled in vertebrates. Our recent work suggests that FGFs are active in two steps of limb development; initiation of buds and subsequent outgrowth. We will apply FGF to chick embryos to examine underlying mechanisms. We will examine whether the same principles operate in mammalian embryos. We will use our knowledge about the role of FGFs in vertebrate limb development to examine the basis of limblessness in snakes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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