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Fine scale mapping of loci influencing growth rate

Reference	G02399
Principal Investigator / Supervisor	Professor Peter Keightley
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	203,415
Status	Completed
Type	Research Grant
Start date	01/03/1995
End date	01/10/1998
Duration	43 months

Abstract

Previously, we have identified quantitative trait loci (QTL) that influence growth rate in selected lines of mice. We now propose to map these loci to a resolution of 1cM, and measure their effects on correlated traits. Molecular markers will be used to back-cross short chromosome segments onto an inbred background to generate partially congenic lines. The presence of QTL in a segment will be ascertained by measuring phenotypic differences between lines congenic for the presence or absence of the segment. The procedure will allow progress beyond coarse scale mapping to a scale at which, in conjunction with information from the mouse genome mapping project, the identification of YAC clones containing QTL and eventual identification of the QTL will be possible.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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