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Studies on cellular signalling events associated with haemopoietic stem cell differentiation and development
Reference
G02274
Principal Investigator / Supervisor
Professor Anthony David Whetton
Co-Investigators /
Co-Supervisors
Dr Clare Heyworth
,
Dr Elaine Spooncer
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
221,909
Status
Completed
Type
Research Grant
Start date
04/01/1995
End date
04/03/1998
Duration
38 months
Abstract
Pluripotent haemopoietic stem cell proliferation and development is regulated by a family of cytokines. One such cytokine Granulocyte Macrophage Colony Factor (GM-CSF) binds to a cell surface receptor to elicit both proliferative and developmental responses in progenitor cells. To identify the receptor domains associated with proliferation and development respectively, mutated GM-CSF receptors will be transferred into a multipotent stem cell line using retroviral gene delivery system. The cellular signalling events associated with proliferative and/or developmental responses will then be identified using these ectopically expressed receptor mutants.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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