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The function of activating regions 2 and 3 during transcription activation by the E. coli cyclic AMP receptor
Reference
G01945
Principal Investigator / Supervisor
Professor Steve Busby
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Geography, Earth & Env Sciences
Funding type
Research
Value (£)
129,485
Status
Completed
Type
Research Grant
Start date
01/04/1995
End date
01/05/1998
Duration
37 months
Abstract
(1) To identify the amino acid side chains in Activating Regions 2 and 3 of the E. coli cyclic AMP receptor, that make direct contact with RNA polymerase during transcription activation. (2) To use biochemical and genetic methods to show that regions 2 and 3 contact the sigma subunit of RNA polymerase, to locate the contact site in sigma, and to understand the consequences of the contact. (3) To investigate cyclic AMP receptor-RNA polymerase contacts at promoters where activation is dependent on tandemly-bound receptor dimers.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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