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Molecular genetic analysis of cytochrome c synthesis and targeting in Escherichia coli

Reference	G01944
Principal Investigator / Supervisor	Professor Jeffrey Cole
Co-Investigators / Co-Supervisors
Institution	University of Birmingham
Department	Sch of Geography, Earth & Env Sciences
Funding type	Research
Value (£)	142,599
Status	Completed
Type	Research Grant
Start date	01/11/1994
End date	01/11/1997
Duration	36 months

Abstract

Our objective is to discover how bacterial c-type cytochromes are assembled from haem and apoprotein precursors and targeted to the E. coli periplasm. Mutants and cloned genes already isolated in this laboratory will first be characterised. A mutant deleted for six recently- identified genes will be constructed and complementary DNA will be cloned from a phage library. Three probes for protein targeting or haem attachment will be used to identify genes for a haem lyase, how haem or cytochromes are transported across the membrane and the site of haem attachment.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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