Award details

Metabolic and developmental control of the expression of genes encoding glyoxylate cycle enzymes in plants

Reference	G01771
Principal Investigator / Supervisor	Dr S Smith
Co-Investigators / Co-Supervisors	Professor Chris Leaver
Institution	University of Edinburgh
Department	Inst of Cell and Molecular Biology
Funding type	Research
Value (£)	106,024
Status	Completed
Type	Research Grant
Start date	01/10/1994
End date	28/02/1998
Duration	41 months

Abstract

Coordinate transcription of genes encoding glyoxylate cycle enzymes malate synthase and isocitrate lyase is developmentally and metabolically regulated. One DNA-binding protein has been isolated and substantially purified, and three putative cis- acting sequences identified. We intend to purify and clone the gene for the putative trans-acting factor and identify others, using gel retardation and footprinting techniques. Cis-acting sequences will be further defined and their functions determined by mutagenesis and assay in protoplasts and transgenic plants. The aims are to distinguish metabolic and developmental mechanisms of control, and to investigate the signal transduction pathways that regulate the synthesis of these key enzymes involved in lipid metabolism. (Joint with grant G01783).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G01783 Metabolic and developmental control of the expression of genes encoding glyoxylate cycle enzymes in plants

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