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Negative regulation of gene expression during stage differentiation in Theileria annulata
Reference
G01329
Principal Investigator / Supervisor
Professor Brian Shiels
Co-Investigators /
Co-Supervisors
Professor Andrew Tait
Institution
University of Glasgow
Department
Wellcome Ctr For Veterinary Parasitology
Funding type
Research
Value (£)
196,755
Status
Completed
Type
Research Grant
Start date
01/01/1994
End date
01/06/1997
Duration
41 months
Abstract
The mechanisms involved in stage differentiation of Apicomplexan parasites will be studied using an in vitro system developed for Theileria annulata. In particular, a gene encoding a macroschizont polypeptide which is negatively regulated during differentiation to the merozoite will be cloned and characterised. The level of gene expression at which negative regulation operates will be determined, and compared, in a temporal manner, with the mechanism employed to up-regulate merozoite gene expression. Such a study will indicate whether these two events are mechanistically and/or temporally coordinated by the differentiation process.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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