Award details

The molecular genetics of internal initiation of translation in yeast

Reference	G01076
Principal Investigator / Supervisor	Professor Emeritus Mick Tuite
Co-Investigators / Co-Supervisors	Professor Richard Jackson
Institution	University of Kent
Department	University of Kent Department
Funding type	Research
Value (£)	254,750
Status	Completed
Type	Research Grant
Start date	01/03/1994
End date	31/03/1998
Duration	49 months

Abstract

Initiation of translation of some eukaryotic viral RNAs eg EMCV, FMDV occurs by direct entry at a site internal within the RNA, the so-called internal ribosome entry segment or IRES. By exploiting the power of yeast molecular genetics the role of both cis- and trans-acting factors, important for viral IRES function, will be defined. In addition, endogenous cellular yeast mRNAs which are translated via an IRES will be identified and characterised and a comparative analysis of internal initiation in yeast and higher eukaryotes undertaken. This work will provide important new insights into this unusual mode of translation and, in a wider context, to a range of biological problems including virus tissue tropism and disease resistance.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search