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Generating a large population of Ds gene-trap and activation trap insertions in the Arabidopsis genome

Reference	FGT11378
Principal Investigator / Supervisor	Professor Michael Bevan
Co-Investigators / Co-Supervisors	Professor George Coupland, Professor Dame Caroline Dean
Institution	John Innes Centre
Department	Cell and Develop Biology
Funding type	Research
Value (£)	429,678
Status	Completed
Type	Research Grant
Start date	01/12/1999
End date	01/12/2002
Duration	36 months

Abstract

The planned work aims to generate up to 30,000 new gene disruptions in the Arabidopsis genome using a novel strategy that exploits Ds transposons to insert preferentially within 1-2 Mb of the launching pad. Regions of interest can be saturated with transposon insertions, and a wide distribution of high-density insertions in the genome can also be made using mapped launching pads. Transposons that reveal cell-specific and quantitative expression levels of disrupted genes, and that over-expresses target genes will be used. A database showing expression patterns, phenotypes and the sequence of insertion sites will be available from the NASC.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Functional Genomics Toolkit (FGT) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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