Award details

Age-related changes in neuroendocrine signalling characterisationunderlying mechanisms and functional rescue

Reference	ERA16326
Principal Investigator / Supervisor	Professor Colin Ingram
Co-Investigators / Co-Supervisors
Institution	Newcastle University
Department	Institute of Neuroscience
Funding type	Research
Value (£)	204,758
Status	Completed
Type	Research Grant
Start date	30/09/2002
End date	29/03/2008
Duration	66 months

Abstract

The hypothalamo-pituitary-adrenal and pineal axes are the principal circadian signals to gene transcription and cellular activity in the body. disregulation of these rhythms underlie many aspects of age-related decline. Using in vivo blood sampling and in situ hybridization, this project will characterise the molecular and functional changes that occur in HPA and pineal rhythms during normal ageing, and test the hypothesis that declining AVP expression in the SCN is a key element to these changes. Functional recovery will be tested by i.c.v. infusion of AVP or by increasing endogenous AVP by increased environmental light. These data will provide the potential for rational development of interventions to improve health quality in ageing.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Experimental Research on Ageing (ERA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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