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Soft tissue ageing is characterised by a failure of matrix synthesis and the accumulation of fragmented matrix proteins
Reference
ERA16303
Principal Investigator / Supervisor
Professor Roger Smith
Co-Investigators /
Co-Supervisors
Professor Andrew Pitsillides
Institution
Royal Veterinary College
Department
Clinical Sciences and Services
Funding type
Research
Value (£)
202,728
Status
Completed
Type
Research Grant
Start date
03/02/2003
End date
03/02/2006
Duration
36 months
Abstract
Failure of the functional competence of skeletal connective tissues, including tendons, is increasing with population age. This study will investigate the hypothesis that tendons fail to synthesise appropriate matrix after skeletal maturity, due to growth factor insensitivity and accumulation of matrix protein fragments, which is exacerbated by loading-bearing. Fragmented, but not intact, matrix proteins have profound catabolic effects on cells. Accordingly, in this study the anabolic effect of cyclical load and growth factors on ageing tendon will be assessed, while matrix protein fragmentation will be defined and the effects of individually purified fragments on tendons determined, thereby identifying two potential anti-ageing strategies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Experimental Research on Ageing (ERA) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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