Award details

The impact of replicative senescence on age-related tissue degeneration: an ovine model

ReferenceERA16281
Principal Investigator / Supervisor Professor David Kipling
Co-Investigators /
Co-Supervisors
Dr Terence Davis, Dr Christopher Jones
Institution Cardiff University
DepartmentDivision of Clinical Laboratory Science
Funding typeResearch
Value (£) 205,596
StatusCompleted
TypeResearch Grant
Start date 01/03/2002
End date 31/08/2005
Duration42 months

Abstract

A primary requirement for a suitable animal model of human ageing is that an equivalent mechanism of replicative senescence is present. We have shown that ovine fibroblasts senesce with shortened telomeres and that the issue expression pattern of telomerase is similar to humans. To address the effect of removing telomere-dependent senescence (TDS) and its effect on ageing we will clone sheep telomerase (sTERT) and study its effect on TDS in vitro. We will then produce a transgenic sheep constitutively expressing telomerase in all tissues. We will subsequently monitor these animals over a period of years to determine the effect of age-related change in proliferative tissues.

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Experimental Research on Ageing (ERA) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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