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The impact of replicative senescence on age-related tissue degeneration: an ovine model

Reference	ERA16281
Principal Investigator / Supervisor	Professor David Kipling
Co-Investigators / Co-Supervisors	Dr Terence Davis, Dr Christopher Jones
Institution	Cardiff University
Department	Division of Clinical Laboratory Science
Funding type	Research
Value (£)	205,596
Status	Completed
Type	Research Grant
Start date	01/03/2002
End date	31/08/2005
Duration	42 months

Abstract

A primary requirement for a suitable animal model of human ageing is that an equivalent mechanism of replicative senescence is present. We have shown that ovine fibroblasts senesce with shortened telomeres and that the issue expression pattern of telomerase is similar to humans. To address the effect of removing telomere-dependent senescence (TDS) and its effect on ageing we will clone sheep telomerase (sTERT) and study its effect on TDS in vitro. We will then produce a transgenic sheep constitutively expressing telomerase in all tissues. We will subsequently monitor these animals over a period of years to determine the effect of age-related change in proliferative tissues.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Experimental Research on Ageing (ERA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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