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Modification of Il-7 and the reversal of thymic involution in aged mice
Reference
ERA16279
Principal Investigator / Supervisor
Professor Richard Aspinall
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
221,288
Status
Completed
Type
Research Grant
Start date
03/04/2002
End date
02/07/2005
Duration
39 months
Abstract
Age associated thymic atrophy leading to a reduction in thymic output may be a key precipitating event leading to immune insufficiency. Our recent results show that treatment of aged animals with IL-7 leads to renewed thymopoiesis and an improvement in the ability of T cells from treated animals to respond in in vitro assays compared with controls. This application proposes to determine whether modification of IL-7; to either improve its half life in the tissues, or to target it to the thymus, will improve its ability to reverse thymic atrophy. In addition we will test whether prevention of proliferation within the memory cells compartment will provide space within the peripheral T cell pool to allow for entry of the new thymic emigrants.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Experimental Research on Ageing (ERA) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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