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The basis for decreased responsiveness to immune challenge in the elderly in vivo
Reference
ERA16274
Principal Investigator / Supervisor
Professor Arne Akbar
Co-Investigators /
Co-Supervisors
Dr Fiona Plunkett
Institution
University College London
Department
Department of Clinical Immunology
Funding type
Research
Value (£)
197,656
Status
Completed
Type
Research Grant
Start date
01/02/2002
End date
31/07/2005
Duration
42 months
Abstract
Old individuals have decreased ability to respond to recall antigens in vivo. We propose to investigate the basis for this lack of responsiveness by injecting purified protein derivative (PPD) into the skin of these subjects and analysing the kinetics of the reaction in two ways. First by histological analysis of biopsies and second by direct measurement of cells and mediators in suction blisters induced at the site of injection. The kinetics of the response of old and young individuals will be compared. We will investigate if the decreased response may be due to 1) defective migration of leucocytes into the lesion 2) altered turnover of leucocytes and 3) increased inhibition by CD4+CD25+ regulatory T cells.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Experimental Research on Ageing (ERA) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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