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Linking senescence and tissue degeneration through Werner's syndrome
Reference
ERA16270
Principal Investigator / Supervisor
Professor Richard Faragher
Co-Investigators /
Co-Supervisors
Institution
University of Brighton
Department
Sch of Pharmacy & Biomolecular Sciences
Funding type
Research
Value (£)
202,828
Status
Completed
Type
Research Grant
Start date
01/12/2002
End date
01/12/2005
Duration
36 months
Abstract
The senescence of mitotic cells has been proposed to play a contributory role in the ageing process. This hypothesis predicts that the accelerated accumulation of senescent cells will cause the premature degeneration of a mitotic tissue. Werner's syndrome provides a powerful system to test the hypothesis because it is associated with premature cell senescence and with the accelerated ageing of certain tissues. However many tissues are unaffected by the disease. We seek to determine if premature cell senescence can be observed in cells from unaffected tissues. If so this will provide powerful evidence against the hypothesis that senescent cells cause ageing. Conversely a lack of cell senescence in unaffected tissues will strengthen the theory.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Experimental Research on Ageing (ERA) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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