BBSRC Portfolio Analyser
Award details
Extracellular reactive oxygen species as propagators of tissue ageing
Reference
ERA16251
Principal Investigator / Supervisor
Professor Malcolm Jackson
Co-Investigators /
Co-Supervisors
Dr Tony Ashton
,
Professor Anne McArdle
Institution
University of Liverpool
Department
Medicine
Funding type
Research
Value (£)
212,680
Status
Completed
Type
Research Grant
Start date
15/07/2002
End date
14/02/2006
Duration
43 months
Abstract
Ageing is associated with accumulation of oxidative damage to tissues. Skeletal muscle is a major source for generation and release of reactive oxygen species (ROS) into the extracellular space. This study will determine whether ageing modifies ROS release by skeletal muscle leading to increased oxidation of blood components and other tissues. Microdialysis will be used to compare ROS release from muscle of young and old mice following standardised periods of oxidative stress (contractile activity or ischaemia and reperfusion). Oxidation and nitration of plasma proteins and tissues will be examined, as will the possibility that this ageing-related oxidation can be reduced by administration of non-tissue permeable inhibitors of ROS.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Experimental Research on Ageing (ERA) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search