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Gene expression profiling of brain and cognitive ageing in mice
Reference
ERA16250
Principal Investigator / Supervisor
Dr Lawrence Wilkinson
Co-Investigators /
Co-Supervisors
Dr Piers Emson
Institution
Babraham Institute
Department
Cognitive and Behavioural Neuroscience
Funding type
Research
Value (£)
234,580
Status
Completed
Type
Research Grant
Start date
01/02/2002
End date
31/01/2005
Duration
36 months
Abstract
The work will use advanced behavioural and genomics methods to unravel the relationships between the psychological expression of ageing effects and underlying changes in the pattern of gene activity in brain. The experiments will ask questions about the extent to which ageing causes different gene activity changes in different brain areas and the precise relationships between any changes in gene expression and cognitive ageing. The experiments will also determine whether the impact of apparent beneficial practice effects on cognitive functioning in old mice are associated with particular pattern of gene activity. Understanding the molecular basis of such protective effects may help to ameliorate aspects of age-related cognitive decline.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Experimental Research on Ageing (ERA) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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