Award details

Proteomics of yeast ageing

Reference	ERA16235
Principal Investigator / Supervisor	Professor Alan Morgan
Co-Investigators / Co-Supervisors	Professor Stephen Pennington
Institution	University of Liverpool
Department	Physiology
Funding type	Research
Value (£)	238,312
Status	Completed
Type	Research Grant
Start date	11/03/2002
End date	10/06/2005
Duration	39 months

Abstract

Recent work suggests that the underlying causes of cellular ageing may be similar in all eukaryotes. We aim to understand this process at the molecular level by studying the simplest organism known to undergo ageing, Saccharomyces cerevisiae. Our approach will be to characterise the changes in cellular proteins that accompany normal ageing using 2D gel/mass spectrometry methods. To identify key proteins that protect against cellular ageing, the same approach will be applied to isogenic long-lived strains. Proteins whose normal age-related changes are reversed in long-lived strains will be tested for a functional role in ageing by molecular genetic manipulation followed by lifespan analysis. These studies will provide a comprehensive characterisation of the molecular basis of yeast ageing and may reveal the key longevity proteins acting at the heart of cellular ageing.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Experimental Research on Ageing (ERA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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