Award details

Cost of reproductioncaloric restrictionoxidative damage and ageing in Drosophila

Reference	ERA16222
Principal Investigator / Supervisor	Professor Linda Partridge
Co-Investigators / Co-Supervisors	Professor Tracey Chapman
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	307,352
Status	Completed
Type	Research Grant
Start date	09/04/2002
End date	08/08/2005
Duration	40 months

Abstract

The aim is to understand how lowered reproductive rate and caloric restriction slow ageing in Drosophila, and to test the nutrient allocation hypothesis. Reproduction and the action of the two main hormones controlling reproduction will be abolished. The role of costly aspects of reproduction in slowing ageing by caloric restriction will then be assessed. Mechanisms controlling the response to caloric restriction will be investigated by transcription profiling of flies during the response to altered nutrition. The role of reduced oxidative damage in mediating slowed ageing by both interventions will be assessed by measuring levels of damage to proteins and lipids, activity of cellular defences against superoxide, mitochondrial activity and density and by measuring interactions with manipulation of antioxidant defence mechanisms.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Experimental Research on Ageing (ERA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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