Award details

Provision of enhancements for a high resolution electron microscopy facility for structural biology within the Krebs Institute

Reference	EII07014
Principal Investigator / Supervisor	Professor Per Bullough
Co-Investigators / Co-Supervisors	Professor David Rice
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	285,144
Status	Completed
Type	Research Grant
Start date	02/04/1996
End date	02/04/1997
Duration	12 months

Abstract

We request support for enhancements to a 200kV electron microscope and associated cryotransfer and specimen preparation equipment. This will create a facility for high resolution electron microscopy of biological molecules within the biological structure group in the Krebs Institute at Sheffield University. Major research programmes which will use the new facilities will involve structure determination of membrane proteins from 2D crystals including components of bacterial photosynthetic apparatus, eukaryotic channel proteins, bacterial antibiotic transporters and viral membrane fusion proteins. Structure determination at low resolution of non-crystalline protein complexes will include analysis of the ruv complex involved in homologous recombination.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Equipment and Industry Initiative (EII) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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