BBSRC Portfolio Analyser
Award details
Provision of high resolution electron microscopy facility for structural biology within the Krebs Institute
Reference
EII05700
Principal Investigator / Supervisor
Professor Per Bullough
Co-Investigators /
Co-Supervisors
Professor David Rice
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
224,884
Status
Completed
Type
Research Grant
Start date
28/03/1996
End date
28/03/1999
Duration
36 months
Abstract
We request support for a 200kV electron microscope and associated cryotransfer and specimen preparation equipment. This will create a facility for high resolution electron microscopy of biological molecules within the biological structure group in the Krebs Institute at Sheffield University. Major research programmes which will use the new facilities will involve structure determination of membrane proteins from 2D crystals including components of bacterial photosynthetic apparatus, eukaryotic channel proteins, bacterial antibiotic transporters and viral membrane fusion proteins. Structure determination at low resolution of non-antibiotic transporters and viral membrane fusion proteins. Structure determination at low resolution of non- crystalline protein complexes will include analysis of the ruv complex involved in homologous recombination.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Equipment and Industry Initiative (EII) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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