Award details

Nanometre scale arrays for biological analysis : towards a new generation of tools for post-genomic research

Reference	EGM17711
Principal Investigator / Supervisor	Professor Graham Leggett
Co-Investigators / Co-Supervisors	Professor Nick Goddard
Institution	University of Sheffield
Department	Chemistry
Funding type	Research
Value (£)	565,636
Status	Completed
Type	Research Grant
Start date	18/03/2003
End date	17/03/2006
Duration	36 months

Abstract

Using a new technique developed at UMIST, scanning near-field lithography of self-assembled monolayers, we create nanometre scale arrays of immobilised antibodies and oligonucleotides. These will form the basis of a novel detection system capable of delivering the ultra-high sensitivity detection sensitivity required for post-genomic research. State-of-the-art nanofabrication and surface functionalisation methods will be combined with microfluidic systems to facilitate rapid preparation of arrays of immobilised biomolecules. Fluorescence detection, utilising scanning near-field optical microscopy, will be explored as a potential route to the addressing of such arrays. We hope to deliver a working analytical system capable of widespread use by researchers working in post-genomic technology.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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