Award details

Lipidomics: metabolic profiling of lipids using array technology

Reference	EGM16109
Principal Investigator / Supervisor	Dr Rudiger Woscholski
Co-Investigators / Co-Supervisors	Professor Anthony Cass
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	175,160
Status	Completed
Type	Research Grant
Start date	01/08/2002
End date	01/08/2004
Duration	24 months

Abstract

We are proposing to synthesise a library of small fluorescent probe molecules that will recognise strongly acidic phospholipids, which are important mediators of cellular signalling. These probes will be chemically altered to generate a family of compounds with differing fluorescent responses to different lipids. They will then be linked, through a PEG tether, to a glass surface forming the basis of an array detector. It is anticipated that the array will produce a fluorescence pattern, reflecting the amount and type of phospholipids present. This proposal pioneers metabolic profiling by array technology, without the need for protein probes. These arrays would combine high throughput capability with robustness.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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