Award details

Integrating proteomics and microelectronics

Reference	EGM16073
Principal Investigator / Supervisor	Professor Bernard Connolly
Co-Investigators / Co-Supervisors	Dr Benjamin Horrocks, Professor Andrew Houlton, Professor Jeremy Lakey
Institution	Newcastle University
Department	Inst for Cell and Molecular Biosciences
Funding type	Research
Value (£)	301,544
Status	Completed
Type	Research Grant
Start date	01/03/2002
End date	01/03/2005
Duration	36 months

Abstract

We propose to develop the use of semi-conducting silicon surfaces as a proteomics platform. Proteins will be covalently attached to silicon in defined arrays. Such arrays will be useful for the massive parallel detection, based on electrochemical sensing, of protein-small molecule and protein-protein interactions. Silicon surfaces will also be used for 2-dimensional capillary electrophoretic separation of proteins, enabling evaluation of the proteome i.e. the protein composition of cells. The advantages of semi-conducting silicon are the possibility of electrochemical sensing and simple integration into microelectronic devices. Silicon is also directly compatible with MALDI-TOF MS for protein identification. The favourable properties of this material should make it invaluable in post-genomic science, especially proteomics.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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