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Direct laser desorption mass spectrometry for high-throughput metabolomics

Reference	EGM16061
Principal Investigator / Supervisor	Professor Royston Goodacre
Co-Investigators / Co-Supervisors	Dr David Broadhurst, Dr Tudor Jenkins, Professor Douglas Kell
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	433,408
Status	Completed
Type	Research Grant
Start date	19/02/2003
End date	18/09/2006
Duration	43 months

Abstract

Based on a recent demonstration that porous Si can serve as a very useful substrate for direct laser desorption ionisation of small biomolecules, (i) to exploit the methods of evolutionary computing to prepare materials in which the ionisation efficiency is optimised, (ii) to measure a suite of physical and spectroscopic properties of the materials so produced, (iii) thereby to understand the mechanism of what determines the efficiency of the laser desorption ionisation process, (iv) to exploit other materials including direct band-gap semi- conductors that - for the mechanistic reasons established earlier - will allow even better efficiencies of laser desorption ionisation, and (v) to exploit the approach in maximising the throughput of sample analysis in metabolomics so as to achieve rates of thousands of metabolome samples per hour.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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