Award details

The cilium/flagellum proteome in human health and disease

Reference	EGH17741
Principal Investigator / Supervisor	Dr Paul McKean
Co-Investigators / Co-Supervisors
Institution	Lancaster University
Department	Biological Sciences
Funding type	Research
Value (£)	306,284
Status	Completed
Type	Research Grant
Start date	01/06/2003
End date	01/06/2007
Duration	48 months

Abstract

Cilia and flagella have undoubted functions in reproductive and respiratory tracts and in vision and other sensory inputs, such as odour detection. We know most about these organelles from inherited diseases and other pathobiologies associated with each of these functions. Unfortunately, we know little of the molecular composition of these important organelles of human cells. Our specific aim is to provide a complete proteomic catalogue of components and relate this to functions in human health and disease. The project uses the genome projects of three flagellate trypansomes as well as the human genome. It exploits the advanced post-genomic technologies available for gene silencing in these microbes along with advanced bioinformatics to define the proteome, then gene functions so providing insight to new biology and its exploitation. (Joint with grants 17729 and 17742)

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

EGH17729 The cilium/flagellum proteome in human health disease

EGH17742 The cilium/flagellum proteome in human health and disease

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