Award details

Defining the mechanism of telomere-independent senescence (TIS) using transcriptional profiling

Reference	EGH16151
Principal Investigator / Supervisor	Professor David Kipling
Co-Investigators / Co-Supervisors	Professor Richard Faragher, Dr Sarah Forbes-Robertson, Dr Christopher Jones, Dr Corrin Wallis
Institution	Cardiff University
Department	Division of Clinical Laboratory Science
Funding type	Research
Value (£)	561,988
Status	Completed
Type	Research Grant
Start date	09/09/2002
End date	08/11/2006
Duration	50 months

Abstract

The finite in vitro division potential of well-differentiated normal human cell poses a significant problem for the pharmaceutical industry has yet to be adequately solved. Although for some human cell types essentially normal cell lines can now be produced by telomerase immortalisation, many of the most useful types display telomere independent senescence (TIS) and are refractory to this approach. We will expression profile a panel of cell types undergoing TIS using conditions which modulate the pathway. The principal genetic elements controlling the pathway will be defined allowing rapid progress in the production of novel differentiated cell lines that display an unlimited lifespan and possess significant pharmaceutical value. (Joint with grant 107/EGH16152).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

EGH16152 Defining the mechanism of telomere-independent senescence (TIS) using transcriptional profiling

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