Award details

Shared genetic pathways in cell number control

Reference	EGH16106
Principal Investigator / Supervisor	Professor Andrew Wyllie
Co-Investigators / Co-Supervisors	Professor Nabeel Affara, Dr Samuel Aparicio, Professor Carlos Caldas, Prof Dr Martyn Caldwell, Professor Charles ffrench-Constant, Professor David MacKay, Professor Stephen O'Rahilly, Professor Stephen Smith, Professor Azim Surani, Professor Christine Watson
Institution	University of Cambridge
Department	Pathology
Funding type	Research
Value (£)	1,783,608
Status	Completed
Type	Research Grant
Start date	01/05/2002
End date	31/10/2008
Duration	78 months

Abstract

Comprehensive gene sets for mouse and human will be used to dissect the shared genetic pathways that regulate the differentiation and programmed cell death of stem cells committed to particular lineages. This will involve the use of cDNA microarrays for both mouse and human and in vivo and culture systems modelling stem cell differentiation and apoptosis. A key element in the analysis of the data will be the application of novel methods to extract meaningful biological information from transcription profiling experiments. The new software has been developed at Cambridge and is based on a method known as Latent Variable Analysis. Understanding of these genetic pathways offers routes into the manipulation of cellular differentiation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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