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Procine reproductive and respiratory syndrome (PRRS) - genetics of host responses

ReferenceEGA16309
Principal Investigator / Supervisor Professor Jane Rogers
Co-Investigators /
Co-Supervisors		 Professor Nabeel Affara, Professor Alan Archibald, Professor Stephen Bishop, Dr Carole Sargent
Institution Wellcome Trust Sanger Institute
DepartmentWellcome Trust Sanger Institute Department
Funding typeResearch
Value (£) 237,276
StatusCompleted
TypeResearch Grant
Start date 01/04/2002
End date 01/04/2007
Duration60 months

Abstract

Porcine Reproductive and Respiratory Syndrome which is caused by a viral pathogen (PRRSv) is an endemic disease with major effects on pig production. We will investigate the host's response to PRRSv infection in cultured alveolar macrophages and whole animals. We will identify genes involved in the host's response to PRRSv infection by expression profiling using microarray technology. We will identify loci determining the host's response to PRRSv through a genome scan exploiting linkage disequilibrium to single nucleotide polymorphisms. This project represents a paradigm for exploiting genomic and post-genomic knowledge and technology to identify the genes involved in the host's response to infectious disease in pigs. The knowledge acquired from this project will underpin improvements in healthier animal production. (Joint with grants 215/EGA16307 and 8/EGA16308).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Exploiting Genomics: Agri, Food and Environment (EGA) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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