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Global gene expression in Escherichia coli: exploitation of genomic data to dissect a model foodborne pathogen

Reference	EGA16107
Principal Investigator / Supervisor	Professor Charles Penn
Co-Investigators / Co-Supervisors	Professor Steve Busby, Professor Jeffrey Cole, Professor Peter Lund, Dr Steve Minchin, Professor Mark Pallen, Professor Christopher Thomas
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	1,320,820
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	30/11/2007
Duration	70 months

Abstract

Escherichia coli uniquely combines foodborne pathogenicity and well-understood molecular biology and physiology. We will form an E. coli genomics centre, building on JIF infrastructure. DNA arrays of O157 and K-12 strains plus additional sequences representing the E. coli horizontal gene pool, with proteomic methods, comparative sequencing, and developments in bioinformatics, will be used to study control pathways and gene expression, underlying bacterial survival and recovery from sub-lethal injury, as well as the evolution of new strains. The work will be directed by a partnership of molecular microbiologists, other academics and end users, leading to transfer of research outcomes and new technologies to industry and the public sector.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Agri, Food and Environment (EGA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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