Award details

Definition of the skeletal muscle degradome; metabolic turnover of the proteome

Reference	EGA16074
Principal Investigator / Supervisor	Professor Robert Beynon
Co-Investigators / Co-Supervisors	Professor Simon James Gaskell
Institution	University of Liverpool
Department	Veterinary Preclinical Science
Funding type	Research
Value (£)	342,476
Status	Completed
Type	Research Grant
Start date	10/06/2002
End date	09/01/2005
Duration	31 months

Abstract

Growth of skeletal muscle reflects an imbalance between rates of protein synthesis and degradation, and optimisation of that imbalance is an important goal in the selection of animals for meat production. However, most studies focus on the dynamics of total protein, which conceals the behaviour of individual proteins. In this proposal, we will apply novel, proteomics-based methods to determine the rates of turnover of the protein complement of chicken skeletal muscle (the degradome) using stable isotope labelling strategies. We will apply these methods to a comparison of chickens selected for rapid growth and those selected for egg production, and at two stages in post-hatching development. This will generate, for the first time, a protein-specific view of the responses of protein turnover in development, and as a consequence of selection.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Agri, Food and Environment (EGA) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search