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Genomic effects on the interaction of cytokines oxidant stress and antioxidant defences

Reference	EFH17753
Principal Investigator / Supervisor	Professor Robert Grimble
Co-Investigators / Co-Supervisors	Dr Robin Armstrong, Professor Philip Calder, Dr William Howell
Institution	University of Southampton
Department	Development Origin of Health and Disease
Funding type	Research
Value (£)	224,060
Status	Completed
Type	Research Grant
Start date	03/03/2003
End date	02/04/2006
Duration	37 months

Abstract

Inflammation and oxidant production are key parts of immune defence. Oxidants may exacerbate inflammation, by enhancing pro-inflammatory cytokine production, via NFkB activation. Oxidant damage and excessive cytokine production underlie chronic disease. n-3 PUFAs and vitamin E can suppress cytokine production and increases in their intake are important features of recommendations to prevent chronic disease. Levels of cytokine production are influenced by genetic factors (SNPs). We have shown that the ability of n-3 PUFAs to suppress cytokine production relates to individual genotype. Whether a similar phenomenon occurs with vitamin E is unknown. We will study cytokine and oxidant production, by blood leukocytes from individuals with differing levels of oxidant stress (middle aged-men and rheumatoid patients), before and after alpha-tocopherol supplementation. The effects of supplementation will be related to SNPs in genes affecting the level of cytokine production in each subject.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Eating, Food and Health (EFH) [1999-2002]
Funding Scheme	X – not Funded via a specific Funding Scheme

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