Award details

Optimising the intracellular trafficking of dendrimers and dendronised polymers

Reference	E20383
Principal Investigator / Supervisor	Professor Ruth Duncan
Co-Investigators / Co-Supervisors	Professor Arwyn Jones
Institution	Cardiff University
Department	Welsh School of Pharmacy
Funding type	Research
Value (£)	215,769
Status	Completed
Type	Research Grant
Start date	01/12/2003
End date	30/11/2006
Duration	36 months

Abstract

Hyperbranched polymers including dendrimers and dendronised linear polymers offer certain advantages as nano-sized drug carriers. They are monodisperse and display unique 3D architecture. We will investigate systematically the effect of polymer structure on endocytosis, intracellular trafficking and transcytosis with a view to optimising the design of dendrimer-based drug and protein delivery systems. A library of dendrimer and dendronised polymer probes will be synthesised and their mechanisms of endocytosis and subsequent trafficking quantitated using subcellular fractionation and molecular cell biology techniques. Structures will be optimised to promote and drug delivery by each pathway.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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