Award details

Functional maturation of tissue in vitro in response to biomechanical stimulation

Reference	E20352
Principal Investigator / Supervisor	Professor E Ingham
Co-Investigators / Co-Supervisors	Professor John Fisher, Professor Jennifer Southgate
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	367,049
Status	Completed
Type	Research Grant
Start date	01/01/2004
End date	31/07/2007
Duration	43 months

Abstract

The aims of this project are to develop and evaluate a simulation system that will provide biaxial dynamic cell culture conditions to investigate the effects of the biomechanical environment on functional tissue maturation. The urinary bladder will be used as a model tissue engineered to construct, fabricated from a decellularised matrix, stromal and urothelial cells, to address the hypothesis that an appropriate biomechanical environment will lead to the appearance of (ultra)structural, molecular and biomechanical features associated with a functional organ. The knowledge will be used to develop simulation systems that will provide in vitro models for the study of the interactive physical and biological environment on the development of tissue in vitro and, in the longer term, tissue engineered solutions for clinical implants.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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