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Combining stem cells self-assembling-peptide scaffolds and novel bioreactors in cartilage engineering

ReferenceE20122
Principal Investigator / Supervisor Professor Richard Oreffo
Co-Investigators /
Co-Supervisors
Institution University of Southampton
DepartmentDevelopment Origin of Health and Disease
Funding typeResearch
Value (£) 182,036
StatusCompleted
TypeResearch Grant
Start date 08/03/2004
End date 07/03/2007
Duration36 months

Abstract

To date, attempts to repair or regenerate cartilage have met with limited success at considerable socio-economic cost. Nonetheless, the avascular nature of cartilage and the fact that it comprises just one cell type makes it an attractive target in the area of tissue engineering. We propose that by using selectively isolated and expanded human mesenchymal stem cells in combination with novel peptide-based self-assembling scaffolds within purpose-built bioreactors, it will be possible to create constructs ideally suited to cartilage formation. To achieve this, we describe a unique multidisciplinary research programme across three centres that harnesses expertise in: i) mesenchymal stem cell technology (Southampton); ii) peptide design and self-assembly and nanobiotechnology (Sussex); and iii) bioreactor design, development and tissue modelling (Bath). (Joint with grant numbers 20124 and 20126).

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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