Award details

Enzyme catalysis in solid phase substrates

Reference	E20061/2
Principal Investigator / Supervisor	Professor Sabine Flitsch
Co-Investigators / Co-Supervisors	Professor Rein Ulijn
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	23,015
Status	Completed
Type	Research Grant
Start date	01/02/2006
End date	31/03/2007
Duration	14 months

Abstract

The interaction of proteins with immobilised ligands is increasingly important in areas like solid phase chemistry (biocatalysis) and screening of compound libraries on surfaces . However, there is little fundamental understanding of how the surface influences protein binding and catalysis. This study addresses two issues in biocatalysis on solid phase. 1) What causes the usually slow catalytic rates, and how may it be overcome? How important are factors besides simple accessibility of solid-phase substrates to the enzyme? 2) Effects on equilibrium position of reactions at a solid surface. Understanding gained will be directly applied to the enzymatic solid phase synthesis of dynamic combinatorial libraries to identify novel host-guest interactions (Joint with E20057).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

E20057 Enzyme catalysis on solid phase substrates

E20061 Enzyme catalysis in solid phase substrates

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